#6368 PLATELET TO LYMPHOCYTE RATIO AND SICKLE CELL NEPHROPATHY

Abstract Background and Aims Platelet-to-lymphocyte ratio (PLR) was introduced as cheap readily assessed biologic markers of subclinical inflammation in sickle cell disease. Microalbuminuria hyperfiltration, early Sickle nephropathy (SCN) have been reported to be associated with platelet-to-lymphocyte (PLR). This association has not yet Congolese disease (SCD) children. Therefore, the aim present study assess between PLR kidney SCD children living Democratic Republic Congo (DRC). Method In this cross-sectional study, we investigated 175 from four centers (Kinshasa university clinics, CMMASS, CMD Diamand, Biamba Marie Mutumbo Dikembe) that give a comprehensive care patients. The were calculated full blood count. Elevated albuminuria main outcomes defined by urinary albumin/creatinine (ACR) ≥30 mg/g estimated glomerular filtration (eGFR) >130 ml/min per 1.73 m2 for females >140 males, respectively. Logistic regression analysis used relationship RPL nephropathy. Results Of enrolled, 41(23.4%) 67(38.3%) them presented abnormal observed 90 (51.4%) strongly, significantly independently both (aOR 3,381; IC95% 2, 22-1, 63; p = 0,000) hyperfiltration 19; 95%IC 98 - 22, 25; 0,010). Conclusion shown nearly fifty two out one hundred bear high platelet lymphocyte is strongly